GPCR Inhibition in Treating Lymphoma
نویسندگان
چکیده
G protein-coupled receptors (GPCRs) are important classes of cell surface involved in multiple physiological functions. Aberrant expression, upregulation, and mutation GPCR signaling pathways frequent many types cancers, promoting hyperproliferation, angiogenesis, metastasis. Recent studies showed that alterations GPCRs different lymphoma types. Herein, we review the synthetic strategies to obtain inhibitors, focusing on CXCR4 inhibitors which represent most available market or under preclinical investigations for these diseases.
منابع مشابه
Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma.
The Warburg hypothesis states that aggressive cancers obtain much of their adenosine triphosphate (ATP) by metabolizing glucose directly to lactic acid. As a result of its high tumor selectivity, 3-bromopyruvic acid (3-BrPA), a well-known inhibitor of energy metabolism, has been proposed as a specific anticancer agent. We investigated the effect of 3-BrPA in a mouse model of aggressive metastat...
متن کاملIN VITRO STUDY OF THE EFFECT OF THYMUS VULGARIS ON ALPHA-GLUCOSIDASE ENZYME INHIBITION FOR TREATING DIABETES
Background: Diabetes is a metabolic abnormality in the body caused by the high activity of the α-glucosidase enzyme in the hydrolysis of carbohydrates to glucose. Alpha-glucosidase inhibitors involved in the digestion of carbohydrates, play a key role in controlling diabetes. Thymus vulgaris is a species of flowering plant in the mint family Lamiaceae with a chromosome number of 2n = 30. The es...
متن کاملLate pulmonary complications of treating Hodgkin lymphoma: bleomycin-induced toxicity.
INTRODUCTION Survival of Hodgkin lymphoma (HL) patients has significantly improved in recent decades. The current first-line therapy is doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) ± irradiation and may cause pulmonary toxicity. Strategies to reduce late toxicity as well as increase survival rate are of interest. PATIENTS AND METHODS Pulmonary function of previously treated HL pati...
متن کاملModel organisms in GPCR research
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany (T.L.), Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA (M.M.B.), Department of Anesthesiology, Division of Basic Research and Washington University Pain Center and Department of Anatomy and Neurobiology and Division of Biological and Biomedical Sciences, Wa...
متن کاملConformational Ensembles in GPCR Activation
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2022
ISSN: ['1948-5875']
DOI: https://doi.org/10.1021/acsmedchemlett.1c00600